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Anthony Varghese
Associate Professor
Discipline: Computer Science and Information Systems
Office: 212G South Hall
Phone: 715-425-3335
Email: anthony.varghese@uwrf.edu
Research Interests:
My research involves the simulation of biological systems, specifically cellular electrophysiology. I use the tools of Mathematical Modeling, Numerical Methods for Differential Equations, and High-Performance Computing to address research problems in the area of Cellular Electrophysiology. With the help of numerous collaborators in academia and industry, I also use the techniques of Cell culture, Immunochemistry, and Molecular Biology: PCR, siRNA.
Publications & Presentations:
- Rezaie-Majd, S., Murar J., Nelson, D., Kelly, R., & Varghese, A. (2004). Increased Release of Serotonin from Rat Ileum due to Dexfenfluramine. Forthcoming in American Journal of Physiology.
- Piper, D., Varghese, A., Sanguinetti, M., & Tristani-Firouzi, M. (2003). Gating currents associated with intramembrane charge displacement in HERG potassium channels. Proceedings of the National Academy of Sciences, 100, 10534-10539.
- Kelly, R., Murar J., Hong, Z., Nelson, D., & Hong, F. (2003). Low potassium dextran lung preservation solution reduces reactive oxygen species production. Annals of Thoracic Surgery, 75 (6), 1705-1710.
- Varghese, A. & Boland, L. (2002). Computing transient gating charge movement of voltage-dependent ion channels. Journal of Computational Neuroscience , 12 (2), 123-37.
- Lu, Y., Mahaut-Smith M., Varghese, A., Huang, C., & Kemp, P. (2001). Effects of premature stimulation on HERG K+ channels. Journal of Physiology, 537 (3), 843-851.
- Bahring, R., Boland L., Varghese, A., Gebauer, M., & Pongs, O. (2001). Kinetic analysis of open- and closed-state inactivation transitions in human Kv4.2 A-type potassium channels. Journal of Physiology, 535 (1), 65-81.
- Nash, M., Thornton J., Sears, C., Varghese, A., & ONeill, M. (2001). Ventricular activation during sympathetic imbalance and its computational reconstruction. Journal of Applied Physiology, 90 (1), 287-298.
- 2004: Zhang, M. , Liu J., Varghese, A., Jiang, M., & Tseng, G. N., "Which positively charged residues in the s4 domain of the HERG channel are involved in voltage-dependent gating processes?," Biophysical Society Meeting, held in Baltimore, Maryland, February 2004.
- 2003: Varghese, A. , Lu Y., Mahaut-Smith, M., Huang, C., & Vandenberg, J., "Temperature dependence of HERG inactivation," Biophysical Society Meeting, held in San Antonio, Texas, March 2003.
- 2001: Varghese, A. , Lu Y., Mahaut-Smith, M., Huang, C., & Vandenberg, J., "Modeling effects of premature stimulation on HERG K+ channels," Biophysical Society Meeting, held in New Orleans, Louisiana, February 2001.
- Hong, Z., Weir, E., Varghese, A., & A, O. (2005). Effect of normoxia and hypoxia on K(+) current and membrane potential of fetal rabbit pulmonary artery smooth muscle. Forthcoming in Journal is not in list - being petitioned.
- Weir, E. K., Hong, Z., Varghese, A., Nelson, D., & Olschewski, A. (2005). Redox Signaling in Hypoxic Pulmonary Vasoconstriction. In J. Bhattacharya (Ed.) Cell Signaling in Vascular Inflammation, (pp. 27-33). Totowa, NJ: Humana Press Inc.
- Varghese, A., (2000). Membrane Models. Biomedical Engineering Handbook, 2nd Ed. Boca Raton, FL: CRC Press.
- Weir, E. K., Hong, Z., & Varghese, A. (2004). The serotonin transporter: a vehicle to elucidate pulmonary hypertension? Forthcoming in Circulation Research, 94 (9), 1152-4. (Invited)
- Varghese, A. & Weir, E. K. (2003). T-type calcium current in sickle cell disease: a channel to therapy? . Circulation Research, 93, 274-276. (Invited)
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