UNIVERSITY OF WISCONSIN River Falls

David Rusterholz
Rusterholz_David

David Rusterholz

Professor
member of graduate faculty

Chemistry
Office: 223 Centennial Science Hall
Phone: 715-425-3538

Email: d.b.rusterholz@uwrf.edu

Education:

BA Macalester College 1971 
PhD University of Iowa 1976

Background:

I joined the faculty at UWRF in 1982 and have been predominantly involved in teaching organic chemistry. My background includes education in medicinal chemistry and pharmacology, so I am particularly interested in research projects directed toward the design and organic synthesis of new compounds which have the potential to act as useful drugs.

Courses Taught:

  • Chem 121 General Chemistry Lecture
  • Chem 121L-122L General Chemistry Lab
  • Chem 231-232 Organic Chemistry
  • Chem 236-237 Organic Chemistry Lab
  • Chem 432 Advanced Organic Chemistry
  • Chem 461 Pharmacology
  • Chem 480 Seminar
  • Chem 495 Undergraduate Research

Research Interests:

  • Design and synthesis of organic compounds with drug actions similar to capsaicin, the active substance in hot red peppers
  • Design and synthesis of TRPV1 antagonists; potential new analgesic drugs
  • Investigation of the radical-cation induced Diels Alder reaction
  • Design of new NMR experiments for the undergraduate laboratory

Projects Involving Undergraduate Students:

1. Schroeder, T.L., Reese, A.W. and Rusterholz, D.B., "Synthesis of 5-Methy öl-2,4-hexadienyl 2,4-pentadienyl Ether", presented at the Minnesota Section ACS 36th Annual Undergraduate Research Symposium in Chemistry, St. Scholastica College, Duluth, May 8, 1993

2. Ochoada, J., Krause, A. and Rusterholz, D.B., "Synthesis of Bis(dienyl) ethers for Investigation of the Radical Cation Initiated Diels Alder Reaction" presented at the Minnesota Section ACS 38th Annual Undergraduate Research Symposium in Chemistry, Gustavus Adolphus College, St. Peter, MN, April 29, 1995.

3. Kaneski, E. and Rusterholz, D.B., "The Total Synthesis of the Natural Compound, Pellitorine", presented at the Minnesota Section ACS 39th Annual Undergraduate Research Symposium in Chemistry, River Falls, WI, April 20, 1996.

4. Ochoada, J. and Rusterholz, D.B., "Synthesis of Bis(dienyl)ethers for Investigation of the Radical Cation Intiated Diels Alder Reaction", presented at the Minnesota Section ACS 39th Annual Undergraduate Research Symposium in Chemistry, River Falls, WI, April 20, 1996.

5. Runge ù, K. M. and Rusterholz, D.B., "An Undergraduate Advanced Lab Experiment Illustrating NMR-Spectroscopic Structure Analysis", presented at the Minnesota Section ACS 39th Annual Undergraduate Research Symposium in Chemistry, River Falls, WI, April 20, 1996.

6. Granec, T.L., Nasery, A., Halberg, S. and Rusterholz, D.B., "Synthesis of Homovanillate Esters: Analogs of Capsaicin and Resiniferatoxin" presented at the Minnesota Section ACS 40th Annual Undergraduate Research Symposium in Chemistry, St. Mary's University, Winona, MN, April 26, 1997. 
  
7. Welbes, L, Kuehlwein, K., Henriksen, B. and Rusterholz, D.B., "Synthesis of N-Vanillyl Alkyl-Substituted Cinnamamides as Potential Analgesics Related to Capsaicin" presented at the Minnesota Section ACS 41st Annual Undergraduate Research Symposium in Chemistry, Macalester College, St. Paul, MN, April 18, 1998.

8. Kuehlwein, K.J., Campbell, K.A., Hullopeter, H.M. and Rusterholz, D.B., "Design and Synthesis of Analogs of Capsaicin: Potential New Analgesic Agents" presented at the Minnesota Section ACS 42nd Annual Undergraduate Research Symposium in Chemistry, Carleton College, Northfield, MN, April 17, 1999.

9. Krohn, P.J. and Rusterholz, D.B., "An NMR Study of Brucine: Development of an Undergraduate Advanced Laboratory Experiment" presented at the Minnesota Section ACS 42nd Annual Undergraduate Research Symposium in Chemistry, Carleton College, Northfield, MN, April 17, 1999.

10. Siegmund, L.S. and Rusterholz, D.B., "Preparation of Hexa-2,4- dien-1-yl 3-(3,4-dimethoxyphenyl)-2-propen-1-yl Ether for the Purpose of Investigating the Radical Cation Induced Diels Alder Reaction", presented at the Minnesota Section ACS 42nd Annual Undergraduate Research Symposium in Chemistry, Carleton College, Northfield, MN, April 17, 1999.

11. Welbes, L.L. and Rusterholz, D.B., "Synthesis of meta-Alkylbenzaldehydes" presented at the Minnesota Section ACS 42nd Annual Undergraduate Research Symposium in Chemistry, Carleton College, Northfield, MN, April 17, 1999.