Tony Varghese

Anthony Varghese

Associate Professor

Discipline: Computer Science and Information Systems
Office: 127C South Hall
Phone: (715) 425-3335
Email: anthony.varghese@uwrf.edumail

Research Interests:

  • My research involves the simulation of biological systems, specifically cellular electrophysiology. I use the tools of Mathematical Modeling, Numerical Methods for Differential Equations, and High-Performance Computing to address research problems in the area of Cellular Electrophysiology. With the help of numerous collaborators in academia and industry, I also use the techniques of Cell culture, Immunochemistry, and Molecular Biology: PCR, siRNA.

Academic Degrees 

  • Ph.D.  University of Minnesota,  Minneapolis, MN,  Biomedical Engineering,  1992

  • M.S.  University of Minnesota,  Minneapolis, MN,  Electrical Engineering,  1987

  • B.S.  University of Wisconsin Platteville,  Platteville, WI,  Electrical Engineering,  1983

Articles in Journals 

  • Zhao, J. T., Hill, A. P. , Varghese, A., Cooper, A. A. , Swan, H., PÄIVI J.n> LAITINEN-FORSBLOM, MARK I. REES, JONATHAN R. SKINNER, TERENCE J. CAMPBELL, and JAMIE I. VANDENBERG, (2009).  Not All hERG Pore Domain Mutations Have a Severe Phenotype: G584S Has an Inactivation Gating Defect with Mild Phenotype Compared to G572S, Which Has a Dominant Negative Trafficking Defect and a Severe Phenotype.   Journal of Cardiovascular Electrophysiology, 20, 923-930.  

  • Weir, E. K., Obreztchikova, M., Varghese, A., Cabrera, J. A. , Peterson, D. A. , Z Hong, (2008).  Mechanisms of oxygen sensing: a key to therapy of pulmonary hypertension and patent ductus arteriosus.   British Journal of Pharmacology

  • Otway, R., Vandenberg, J. I. , Guo, G., Varghese, A., & Castro, L. M. (2007).  Stretch-Sensitive KCNQ1 Mutation.   Journal of the American College of Cardiology.
     
  • Hong, Z., Hong, F., Olschewski, A., Cabrera, J., Varghese, A., Nelson DP, Weir EK, (2006).  Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus.   Circulation, 114, 1372-1379.  

  • Varghese, A., TenBroek, E., Coles Jr., J., & Sigg, D. (2006).  Endogenous channels in HEK cells and potential roles in HCN ionic current measurements.   Progress in Biophysics and Molecular Biology, 90 (1), 26-37.  

  • Vandenberg, J. I., Varghese, A., Lu, Y., Bursill, J., Mahaut-Smith, M., C. Huang, (2006).  Temperature dependence of human ether-a-go-go-related gene K+ currents.   American Journal of Physiology, 291 (1), C165-75.  

Articles in Proceedings 

  • Hill, A. P., Varghese, A., Dokos, S., Mann, S., & Vandenberg, J. I. (2009).  Developing In Silico Descriptions Of Herg Channel Gating.   Biophysical Society Meeting, 96 (3 Suppl 1), Elsevier Inc., 191a.  

Courses Taught 

  • C++ Programming

  • Computer Graphics

  • Data Structures and Algorithms

  • Introduction to Bioinformatics

  • Operating Systems

  • Programming I

  • Programming II

  • Software Engineering

  • Special Topics: Computer Science

Varghese, Tony